>Instead make the edges one region and the center another one
That’s commercial HVAC Design 101 stuff. Has been SOP in typical office building HVAC design for many decades.
Zoning costs money, though, and when the entire east face is one zone in a large building, say, results can be less than optimal.
Not to mention when the landlord knocks out a few walls to please a tenant. Or the building wasn't commissioned properly.
Then try to throw daylighting into the mix...
“Zoning costs money”
That’s why my houses with forced air heating have had one zone. We’ve been happy with it.
I’m still using the Honeywell Chronotherm II “setback” thermostat I installed in 1988, too. It’s got features I don’t see on today’s thermostats, like a simple “Hold” button, a simple “Run Program” button (to go back to auto), and a “Prev Period” button to switch back to the previous program setting.