Interesting.
So far, Remicade has me in remission for 4 years but I know its a shotgun approach. A promise of more targeted biologics would be great. Like Entyvio.
I worked on a promising Cathepsin S inhibitor, some years ago, for Crohn’s disease. Unfortunately it never made it out of Phase I trials.
Those guys are super important but can be like teenagers with whiskey and car keys.
I was able to gain some relief by eliminating the fish oil pills I was taking. Like most gelcaps they contain glycerine. This could be a mere glycerol allergy, but I also gained relief from other autoimmune symptoms as well.
I suspect a genetic mutation in my GAPDH (glycerol 3-phosphate dehydrogenase) genes. They are part of the ALDH gene complex. When mutated these genes fail to convert the aldehydes from sugar metabolism into vinegar.
Victims are left with harmful aldehydes which destroy tissue and promote bacterial mimicry. When the COVID is over I intend to get my ALDH-2 and GAPDH genes tested.
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Those must be some thankful mice.