Serrapeptase should be taken on empty stomach, iirc. Also great for keeping arteries clear. I use it in the morning.
All enzymes work on inflammation when taken on an empty stomach. When taken with food, they aid in digestion. Systemic Enzymes are assimilated through our exocrine system and we only have a finate supply. By taking them by mouth, you prolong the supply. They are the single most important protection against abnormal inflammatory processes that occur in the human body.