Corona Virus Daily Thread #51 COVID-19 5/07/2020

many | 5/7/2020 | many

[RummyChick]

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Did European athletes catch coronavirus while competing at World Military Games in Wuhan in OCTOBER? French delegation returned with fevers, after fishmonger is found to have been contaminated in Decembe

https://www.dailymail.co.uk/news/article-8291755/Did-European-athletes-catch-coronavirus-competing-World-Military-Games-Wuhan-OCTOBER.html

[Black Agnes]

They’re scheming to make this the USVirus, not the ChineseVirus.

[Paul R.]

Has anything (study or studies) come out that analyzes likely COVID-19 (or similar diseases) severity vs. viral load / amount of exposure? That is, for example, in settings where heavy exposure might be more likely, are cases tending to be more severe after other risk factors are accounted for?

Obviously, each person has a “threshold” above which they get infected and can be a spreader. But, do increasingly heavy exposures tend to lead to increasingly severe cases?

[Black Agnes]

I think NYC would be an example of that?

Brushing past someone in the produce section of Trader Joe’s in LA and then going to the beach for an ample dose of D3 is WAY different than sitting on a metro north train for 30m next to an infectious person.

[Black Agnes]

https://www.wsj.com/articles/sweden-has-avoided-a-coronavirus-lockdown-its-economy-is-hurting-anyway-11588870062

“The lesson of Sweden, which has almost no coronavirus restrictions, could be that the pandemic will wreck economies whether they have lockdowns or not. Swedish GDP is projected to drop by 7%, in line with countries that have lockdowns”

Shockingly enough, people at risk ARE staying home.

Even WITH an ‘open economy’.

As it turns out, the over 40’s who are at risk are ALSO your big earners. When THEY stay home (because they are at risk), the economy suffers.

Shocker.

[RummyChick]

https://www.wthr.com/article/indiana-coronavirus-updates-gov-update-reopening-pence-staffer-tests-positive-covid-19

ISDH Update
Indiana has received a shipment of Remdesivir from the federal government. ISDH said the medication has been shown to shorten the length of the virus.

The state has analyzed more than 22,000 cases of COVID-19. About 27 percent of those needed a visit to the Emergency Room and 19 percent had to be hospitalized. Of the 4,389 that were hospitalized, 23 percent went into the ICU.

Around 70 percent of those hospitalized have been discharged, 14 percent are likely still hospitalized and 16 percent of the patients died.

[RummyChick]

so if this is under lockdown...I bet they dont have enough Gilead drug if cases rise

Of the 4,389 that were hospitalized, 23 percent went into the ICU.

[mrsmith]

https://www.cdc.gov/coronavirus/2019-ncov/covid-data/covidview/index.html

CDC site info was updated today (weekly info)
LOOKING VERY GOOD!

[DEPcom]

Yes it is looking good. Only State that I see with a steady climb is Ca on Worldometer.

[DEPcom]

Just got the weekly update from work, we have 9 new cases this week.

[RaceBannon]

south carolina open 50% monday

https://twitter.com/AdonisAlbright/status/1258860433282265088?s=20

[LilFarmer]

I have a quick garden question for those who live in colder climates... temps in my area in GA are supposed to get down around 37 at night for the next few nights. I’ve never had to deal with these low temps in May! Do I need to cover anything? I figure tomatoes at least, but beans? Cukes? Zucchini?

[who knows what evil?]

I cover EVERYTHING because I do NOT trust the weather forecasters...ever.

[LilFarmer]

Good point

[who knows what evil?]

9 out of 10 times around here; it never gets quite as cold as predicted, but it’s that TENTH time that ruins everything. I learned my lesson.

[BobL]

Thanks much, Race - almost caught up for the week!

[RummyChick]

medcram has up a new video

in searching how to increase catalase saw claims it can help with gray hair

[RummyChick]

mvbrown25
4 hours ago
MedCram - Medical Lectures Explained CLEARLY I still think Vascular Endothelial Growth Factor is the crux in this disease doctor after researching more into your hypothesis. VEGF is shown in high levels in kawasaki disease and in COVID. Since it’s main role is angiogenesis and permeability, any elevation should, hypothetically, induce the severe symptoms noted in both diseases. VEGF is the single factor consistent in all the co-morbidities for COVID as well. Modulation of VEGF is key I believe. The cocktail I previously prescribed as an adjunct modulates VEGF while still increasing NO production. ADAMTS13, in an attempt to achieve homeostasis from elevated vWF, also elevates VEGF in a way I still don’t fully understand but am working on. Please look into this pathway. There’s a single trial already underway focusing on this exact pathway.

3

[Tolerance Sucks Rocks]

Benton County moves ahead with opening facilities (Arkansas, 5/8/20)

Casinos given May 18 as date to reopen doors; Sharp County has first death (Arkansas, 5/8/20)

Illinois Church Gatherings Of 50+ People May Not Meet For A Year, Gov. Pritzker Says (Illinois, 5/8/20)

Coronavirus in Austin: New stay home orders issued for Austin, Travis County (Texas, 5/8/20)

Coronavirus in Austin: Read the city’s updated ‘stay home’ order (Texas, 5/8/20)

Coronavirus brief: What happened in COVID-19 news yesterday in Sioux City, beyond (Iowa, Nebraska, South Dakota, 5/8/20)

Jobless rate spikes to 14.7%, highest since Great Depression (5/8/20)

Americans more worried about reopening too quickly than not opening quickly enough, survey says (5/8/20)

First child death from mysterious COVID-19-related illness is reported in the U.S (New York, 5/8/20)

Gov. Wolf to move more counties into 'yellow' reopening phase; extends stay-at-home order for ‘red’ counties (Pennsylvania, 5/7/20)

Pittsburgh Parking Authority furloughs all enforcement officers, meter technicians (Pennsylvania, 5/7/20)

Jameson Taillon says even 'rough idea' of return timeline is reason for excitement (MLB, Pennsylvania, 5/7/20)

Fox News Host Calls on ‘Healthy People’ to ‘Have Some Courage’ and Get Infected With Coronavirus (Derp, 5/7/20)

Google employees are told to expect to work from home for the rest of the year, but a select few will be allowed to return to offices as soon as June (5/7/20)

Indian train kills 16 workers laid-off in coronavirus lockdown (India, 5/7/20)

I’m a Former NCAA Runner Who Was Diagnosed With COVID-19. Here’s What It’s Like Running Again (New York, 5/7/20)

Metro Sioux City sees deadliest day yet as five more patients succumb to COVID-19 (Iowa, Nebraska, 5/7/20)

Tyson reopens Dakota City plant; metro leaders offer both optimism and unease (Nebraska, Iowa, 5/7/20)

ICU Docs to Runners: Don’t Let Your Guard Down (5/6/20)

[RummyChick]

In a cursory search higher VEGF is seen in WUhan Flu. They are testing some anti-vegf drugs on it.

Like the kind they shoot you in the eye with

So take VEGF and research it with whatever is wrong with you
Wrapping it around to malaria...beta thalassemia major- kind with transfusions..have high VEGF in children..dont know about adults..if spleen removed even higher VEGF

Alpha thalassemia has high VEGF

they give thalidomide for transfusion people. WOW... https://medcraveonline.com/HTIJ/HTIJ-06-00191.pdf

Thalidomide was previously used to treat multiple myeloma. It has also significant role on HbF. Exact aetiology of its role is not known but it may be due to suppression of NF–KB induction caused by certain inflammatory cytokines including tumor necrotic factor–α (TNF–α), prostaglandin E2 synthesis (PG–E2), and vascular endothelial growth factor (VEGF), in association with increase in release of reactive oxygen species (ROS). Reactive oxygen species launches P38 MAPK, which causes increase in HbF levels.7, 8

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Cytokines play fundamental parts in dys-regulation of the apoptosis of endothelial. The endothelin-1 (ET-1) and VEGF are produced and secreted from a wide spectrum of inflamed cells during vascular insult or hypoxia and are defined as multifunctional growth factors

https://ehoonline.biomedcentral.com/articles/10.1186/s40164-019-0145-x