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so perhaps why Ace inhibitors MIGHT be a problem with covid 19 ..we have seen that theorized but havent really seen a definitive answer. the more I read the more I think this was an experiment for whatever reason that went wrong. why do malaria drugs if given early seem to work when malaria is from a parasite?

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.116.309602

We propose the hypothesis that high levels of Ang II, which cause hypertension, protect against cerebral malaria.

Furthermore, it is important to consider that angiotensin receptor blockers, by shifting circulating Ang II to stimulate the AT2 receptor, may be protective against cerebral malaria, whereas ACE inhibitors would reduce the levels of Ang II, possibly increasing the likelihood of developing cerebral malaria on infection with Pfalciparum. In this context, it may be preferable to use angiotensin receptor blockers rather than ACE inhibitors for the treatment of hypertension in malaria endemic areas or at least in hypertensive patients with malaria.

i cant synthesize this:

Using this paragraph I pulled out the word polymorphisms (btw, one of the COVID drugs suggested test for G6ph before giving it)

"Pfalciparum malaria has coexisted with humans for more than 50 000 years and has profoundly shaped the genetic composition of our species.7 It is well known that polymorphisms causing diseases, such as sickle cell, glucose-6-phosphatase deficiency, ovalocytosis, and thalassemia, have been selected for the protection that they confer against severe malaria.8"

then I got this
The host’s angiotensin-converting enzyme polymorphism may explain epidemiological findings in COVID-19 infections

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102561/
" It should also be noted that the two Asian countries which were initially severely hit by the virus, China and Korea, are also characterized by low D allele frequencies.

These data suggest that ACE1 D/I polymorphism may be regarded as a confounder in the spread of COVID-19 and the outcome of the infection in various European populations. These findings are in agreement with the role of ACE in pulmonary infections caused by corona viruses [4]. The ACE D/I genotype may affect the clinical course of the infection.

Yea, my simple question from the start was how do those tiny Coronavirus virons know if a person has high blood pressure, since hypertension itself doesn’t cause any chemical changes in the human body.

Answer: Since it’s not the hypertension alone, it must be the drugs being used to control the hypertension. Also, it would be interesting to know if hospitals are continuing to give ACE Inhibitors to people already taking them. after they’ve come down with Coronavirus. To me it seems logical to get them off of those drugs immediately - but then again, I’m not an ‘expert’, like those at the CDC. LOL.