btw my relative who succumbed to the cytokine storm had no known underlying issues and did not have thalessemia.
So who knows why the flu wrecked the body in that case
Young, Fit, Athlete but not Super Athlete. Dead in about 4 days from pneumonia/sepsis
more from that yahoo commentor
2nd source https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156948/pdf/main.pdf
There is some stuff coming out from hematologists that is saying.. the virus is acting as if its primary target is the endothelium. Read the reports from Hooman Poor, Adam Cuker and pathologist Sharon Fox. Maybe the secret is not to fight this disease like a respiratory illness, but treat it as a blood/endothelial disorder and immune system gone haywire. Clot busting drugs and anti rejection drugs to modify the cytokine response? Pathologist Fox says when you look at these bodies you see they are riddled with blood clots in the small vessels of the body, the lungs being hit the hardest with clots.
What happens when you breathe the virus in, it’s going to go first into your lungs specifically to the ACE 2 receptor in your lungs. And what we all thought and imagined was that we were going to get ARDS, and that is why we started treating patients with hypoxia. Secondary to ARDS. Because this is what we all have been expecting for months and months.
But the virus gets worse and spreads and then it starts to go into the blood vessels. And the blood vessels inside of them also have ACE 2 receptors. What happens now when it goes into ACE 2, we get thrombosis, AT-11. These things happen so quickly even before the ARDS gets bad enough to cause the H type of lung problem, we have thrombosis which is causing the ground glass opacification, and we get the L type lung problem.
The final common denominator which take most of the patients into ICU is a process known as oxidative stress. The people with the worst oxidative stress from a baseline standpoint are those people with cardiovasular diseases, diabetes and over weight. Happy hypoxics. Cardiovasular collapse, blood clots in their vessels. These are the ones put on ventiators but to little avail.
An understanding of oxidative stress and how it might be involved in COVID-19 may give an avenue for therapeutics.” Have a pulse/O2 oxygen saturation monitor http://blauoximeter.pg-blog.com/ on hand. A pulse oximeter can provide early warning of the kinds of breathing problems associated with Covid-19 pneumonia. Take your readings now, when you are well, so you have a baseline to compare with. And do this lying down (as you would be if sick), so your baseline is a true baseline. Heart rate increases just by sitting up. Knowing these numbers will be very helpful in deciding if you need to seek medical attention.