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Italian scientist says she discovered main mechanism behind COVID-19: Annalisa Chiusolo shows how controversial drug Hydroxychloroquine could make people immune to virus
Jerusalem Post ^ | 05/03/2020 | By MAAYAN JAFFE-HOFFMAN

Posted on 05/03/2020 7:23:38 AM PDT by SeekAndFind

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AS FOR HYDROXYCHLOROQUINE, HERE IS HER THESIS:

As a pharmacist, Chiusolo next evaluated the use of hydroxychloroquine to treat SARS-CoV-2, which in some cases has been found to reduce hospitalizations from the virus. Hydroxychloroquine is currently in use for the treatment of autoimmune diseases worldwide, such as lupus and rheumatoid arthritis, and has been used for years to treat malaria.

She said that in addition to the drug’s antiviral and immunomodulatory effect, it binds to the ferriprotoporphyrin of the ecgonine methyl ester (EME), blocking the key enzyme of malaria. “So, I thought this same mechanism could be used against SARS-CoV-2... Indeed, a study by a Chinese university shows that SARS-CoV-2 binds to the beta chain of hemoglobin, inhibiting EME metabolism.”

Ferriprotoporphyrin is the group responsible for the oxygen binding of hemoglobin.

1 posted on 05/03/2020 7:23:38 AM PDT by SeekAndFind
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To: SeekAndFind

Chiusolo said that hydroxychloroquine could act as a prophylactic, preventing or limiting the symptoms of the disease while waiting for the formulation of the vaccine that specifically stimulates the antibody response of the body. She said it could make the patient immune to COVID-19 and/or limit its side effects.

AS for those who are impatient... sorry, you have to wait some more. According to her:

The Italian Medicines Agency (AIFA), the national authority responsible for drug regulation in Italy, has an approved trial of hydroxychloroquine on 2,500 patients, which will start in early July and focus on the use of hydroxychloroquine in prophylaxis, Chiusolo said. The study, for which preliminary data would be ready within 16 weeks, will look at whether the preventive intake of the drug decreases the probability of contracting COVID-19 when one comes directly into contact with a positive patient.


2 posted on 05/03/2020 7:25:18 AM PDT by SeekAndFind (look at Michigan, it will)
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To: SeekAndFind

For Hydroxychloroquine acting as a prophylaxis, here are her observations:

The International Journal of Antimicrobial Agents describes how a healthcare worker infected with the novel coronavirus traveled freely within a hospital before being diagnosed with the virus.

“It was not possible to quarantine everyone who had come into contact with the healthcare worker,” Chiusolo said. So, they treated 211 healthcare professionals and patients with hydroxychloroquine. After 10 days, nobody tested positive for the coronavirus.

Furthermore, Chiusolo told the Post, the Italian Society of Rheumatology interviewed 1,200 rheumatologists throughout Italy to collect statistics on contagions. Out of an audience of 65,000 chronic lupus and rheumatoid arthritis patients who systematically take hydroxychloroquine, only 20 patients tested positive for the virus.


3 posted on 05/03/2020 7:27:00 AM PDT by SeekAndFind (look at Michigan, it will)
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To: SeekAndFind

OF COURSE, THERE ARE SKEPTICS, ESPECIALLY IN THE USA.

Here is what happened in Beth Israel Deaconess Medical Center (BIDMC) in Boston.:

“The accumulating evidence is that there is limited data to suggest efficacy and there’s growing evidence that suggests toxicity,” Dr. Howard Gold, infectious disease doctor at BIDMC, said of the drug hydroxychloroquine in an interview published by the Boston Herald.

The BIDMC study evaluated 90 adults infected with the novel virus, each of whom received at least one day’s treatment of hydroxychloroquine, which can stay in the body for up to three weeks, according to Gold.

“Scientists are very open to revolutionary ideas,” Goldblum said, but he noted that “science is built in steps… They must have some backing. In my opinion, currently there are none.”


4 posted on 05/03/2020 7:28:22 AM PDT by SeekAndFind (look at Michigan, it will)
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To: SeekAndFind

Related articles:
https://s3-eu-west-1.amazonaws.com/itempdf74155353254prod/11938173/COVID-19_Disease__ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin_v2.pdf

https://www.washingtonpost.com/health/2020/04/22/coronavirus-blood-clots/


5 posted on 05/03/2020 7:28:46 AM PDT by rightwingcrazy (;-,)
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To: SeekAndFind

I’m not a scientist I just play one on freerepublic but these results sounds staggeringly positive.

I’ve not read rebuttals to them in the news, perhaps because there is none.


6 posted on 05/03/2020 7:30:23 AM PDT by dp0622 (Radicals, racists dloont point fingers at me I'm a small town white boy Just tryin to make ends meet)
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To: SeekAndFind

Thank you very much for this information. That seems very promising, especially in light of us learning more about how the virus actually works in the body.

As far as American “scientists” go, I don’t care what they say about absolutely anything at all, but especially on HC, because they have no credibility whatsoever.

It’s amazing that TDS has become an actual contagious mental disease, and they will kill you over it.


7 posted on 05/03/2020 7:34:32 AM PDT by chris37 (China's Gift wasn't born in a bowl of bat soup.)
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To: dp0622

RE: I’ve not read rebuttals to them in the news, perhaps because there is none.

See Post #4 above.


8 posted on 05/03/2020 7:38:17 AM PDT by SeekAndFind (look at Michigan, it will)
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To: SeekAndFind

Lame stream media attack in 3,....2,....


9 posted on 05/03/2020 7:38:20 AM PDT by rktman ( #My2ndAmend! ----- Enlisted in the Navy in '67 to protect folks rights to strip my rights. WTH?)
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To: SeekAndFind
It seems that there are interests that do not want to hear anything positive about HCQ.

Motivations seem to be primarily financial or Trump hatred.

This was some of the best damn anecdotal evidence I've ever heard.

10 posted on 05/03/2020 7:42:04 AM PDT by Aevery_Freeman (AOC has the perfect face for the 'Rat Party - Hee-Haw)
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To: rktman
Chiusolo said that hydroxychloroquine could act as a prophylactic, preventing or limiting the symptoms of the disease while waiting for the formulation of the vaccine that specifically stimulates the antibody response of the body. She said it could make the patient immune to COVID-19 and/or limit its side effects.

This is devastating news for the MSM and communists(democrats.) It must be suppressed, discredited, and absolutely overwhelmed by negative "studies."

Orange Man Bad and citizens must die to prove it.

11 posted on 05/03/2020 7:45:44 AM PDT by Thommas
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To: SeekAndFind

OANN had a female doctor from Florida on a few weeks ago - she explained it all very well...perhaps this Italian “discoverer” saw the broadcast...


12 posted on 05/03/2020 7:52:01 AM PDT by trebb (Don't howl about illegal leeches, or Trump in general, while not donating to FR - it's hypocritical.)
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To: SeekAndFind
The study, for which preliminary data would be ready within 16 weeks, will look at whether the preventive intake of the drug decreases the probability of contracting COVID-19 when one comes directly into contact with a positive patient.

Time moves slow when waiting for a miracle...

13 posted on 05/03/2020 7:52:04 AM PDT by GOPJ (Was misery & death worth the four bucks saved on the crappy waffle-iron 'made in China?)
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To: Thommas

They will probably counter these studies by quoting Dr. jill


14 posted on 05/03/2020 7:52:43 AM PDT by rktman ( #My2ndAmend! ----- Enlisted in the Navy in '67 to protect folks rights to strip my rights. WTH?)
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To: trebb

RE: perhaps this Italian “discoverer” saw the broadcast...

Or the Florida doctor saw the Italian study. Or better still, they came into this discovery INDEPENDENTLY.


15 posted on 05/03/2020 7:53:44 AM PDT by SeekAndFind (look at Michigan, it will)
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To: SeekAndFind

Drink Tonic Water and take zinc.


16 posted on 05/03/2020 7:58:18 AM PDT by tinamina
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To: SeekAndFind
COVID-19 damages the hemoglobin, impairing the ability of red blood cells to transport oxygen throughout the body

I've read this in a variety of places over the past week. Seems to me there's something to this.


17 posted on 05/03/2020 8:01:10 AM PDT by Cinnamontea
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To: Aevery_Freeman

The problem is that big pharma doesn’t make a lot of money from HCQ. It’s just that simple. Probably has Gates fingerprints on any denial.


18 posted on 05/03/2020 8:03:56 AM PDT by JayAr36 (The worthless dispicable party must be destroyed)
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To: SeekAndFind
such as the greater vulnerability of men – specifically male diabetics – to become seriously ill from the virus

This is the first time I have seen this explicitly stated anywhere - after 3 months of "news" coverage...

19 posted on 05/03/2020 8:07:55 AM PDT by kiryandil (Chris Wallace: Because someone has to drive the Clown Car)
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To: tinamina
Add a little gin to it if you must. Apparently, that guy Mr. Joel sang about; making love to his tonic and gin, knew what he was doing. 😋
20 posted on 05/03/2020 8:09:55 AM PDT by AFreeBird
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