Figure 1:
https://www.mediterranee-infection.com/wp-content/uploads/2020/04/Capture-d%E2%80%99e%CC%81cran-2020-04-30-a%CC%80-14.28.32.png
Figure 2:
https://www.mediterranee-infection.com/wp-content/uploads/2020/04/Capture-d%E2%80%99e%CC%81cran-2020-04-30-a%CC%80-14.28.14.png
Supplementary dataset:
https://www.mediterranee-infection.com/the-efficacy-of-chloroquine-derivatives-in-covid-19-a-meta-analysis-based-on-the-first-available-reports/
When considering all ten included studies (Figure 1, Table S2), chloroquine derivatives were associated with a lower need for hospitalisation (n = 1, Odds ratio (OR) 0.35, p = .024), shorter duration of cough (n = 1, OR 0.13, p = .001), shorter duration of fever (n = 1, OR 0.14, p = .001), decreased C-reactive protein level (n = 1, OR 0.55, p = .045), and increased hospital discharge (n = 1, 67OR 0.05, p =.050).
CQ derivatives were associated with a beneficial effect (OR < 1) for 11 of the 12 outcomes analysed (Figure 1). Of the comparisons made, 19 were favourable (Table S1).
Accordingly, the two-sided sign-test p-value was 0.015. The fatality rate was analysed in two studies with an opposite direction of effect. The study reporting an increased fatality rate was suspected of scientific misconduct (patientsweresignificantly more severe in the treated group [7]). No significant negative effect was observed.
Outlawed in 1/3 of US States, unless used in Hospital as a last resort, in which case, it does nothing. The most important thing here is orange man bad
>> certain Western countries do not
Comcast behind that agenda
It has been suggested that ventilators have done more harm than good, at least in some cases. Did the medical bureaucracy ever suggest doing a controlled study on their use for CV?
I have been and always will be skeptical of “meta-analysis” of studies - especially medical ones.
That said this is interesting.
Remdesvir(sp?) is patented, and $1000/pill. HCQ is off patent and $0.63/pill. Trump first mentioned HCQ, and the media absolutely shunned it. Three guesses why.
Summary - reality beats academic theory.
The media’s contribution to people’s ignorance about drugs is the media’s over emphasis of what ailment a drug is commonly known to be treated for, leading most people to conclude that a drug known to be commonly used against one ailment (malaria) cannot possibly be beneficial against another ailment (Wuhan Virus).
People need to understand they do not know chemistry, or human chemistry well enough to know why and how most drugs work, and why a drug used against one ailment may even work as well or even better against another ailment, as long as the chemistry of the drug works against the chemical reactions necessary to the agent causing the ailment.
I take a pain med that some decades ago was never thought of as a pain reliever - it was mostly prescribed to epileptics to help prevent epileptic seizures.
In actuality medical science is still not totally sure how it works a a nerve pain reliever (it is not metabolized in the body, is expelled in its whole form in the urine, does not get combined with other chemicals in the body). They do know it does manage to cross the blood-brain barrier. But - they are unsure exactly how it works - what they do know is the mere presence of the chemical/drug in the chemistry in the brain causes a change (they are not sure how) in the neuro-chemical reactions of neurotransmitters in the brain. Had that reality not been acknowledged they may never have admitted its use in fighting pain, for its chemical mechanism was not looked for and is still not fully understood - only that it does work.
You can be sure if such a drug with such not fully understood mechanism was tried for fighting the Wuhan Virus and those efforts were successful, it would be panned by the media, the FDA and all the “experts”, because it could not be explained exactly how it worked, so it would never pass the tests for getting “officially” approved.