I’ve been following what has been posted here with some interest about the illness itself. A couple things that people seem to be “assuming” are irreconcilable, IMHO. You can’t be “getting worse because you have no immunity to the ‘novel’ virus” and then hours later have “Cytokine Storm”. Seems to me you have one or the other but not both. Right along it seemed to me what people have described is a viremia that attacks all the cells the virus is exposed to. The “entry” is “Pulmonary” because it spreads via droplet or aerosol. But from there it is a one or two cell layer trip to the vascular system. The cells that are exposed next are the vascular endothelium and the cells of the circulating blood.
As the vascular endothelial cells are killed the underlying “basement membrane” is exposed and this is a very thrombogenic substance. So very early on the body “sees” a shower of circulating micro emboli. Hence the “blue toes” as these emboli are trapped in the “U shaped” capillaries.
The brain is one organ that “sees” this shower of microemboli and like the heart the brain is nothing but dead end arterioles. So no emboli that go to the brain leave it. Same with the Kidney. So unless I miss my guess, these are the organs that take the worst of it in the early stages and during this part of the illness the patients really have almost no symptoms. The emboli are microscopic.
Sounds like if for some reason (who knows what it is?) IF the viremia stops this is as far as the disease progresses. If it continues the illness progresses. So what could make the virus stop? A healthy immune system, perhaps. Sounds logical.
But what if? What if this virus loses it’s Ro and CFR characteristics in transmission from person to person rapidly? If that is taking place so rapidly could a virus actually go through “enough passages” inside one person during one illness such that it starts out highly pathogenic and then just “runs out of steam” part way through? I don’t think anyone has ever proposed such a thing could happen but with a “manipulated” virus that can’t hold the characteristics it has been manipulated to have?
Think about it, we are talking about Ro’s and “generations” that are in the hundreds considering transmission host to host but INSIDE one person the illness progresses through thousands of generations. Could it be that when a patient begins the illness the virus they are spreading is highly virulent but when they are down and out the virus that is circulating is less virulent?
Just a thought.
Interesting
So would all these strange symptoms be more likely in an engineered virus?
And maybe some of the people talking about things being worse in the fall, are thinking about mutations?
Thank you for your posts.