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To: RummyChick

from texags
https://texags.com/forums/84/topics/3099401/0
“So since I had multiple people ask me to research N-acetylcysteine (NAC) Let’s discuss it.

N-acetylcysteine (NAC) is the medication we commonly use in medicine for tylenol overdose. It works by helping regulate glutamate levels and replenish glutathione. Glutathione is an antioxidant that helps break down free radicals and damage cells in your body. Basically it is an antioxidant that helps the liver get rid of toxins. It was studied in H1N1 influenza with a dose of 600mg twice per day for 6 months. Even though the incidence of influenza was not decreased the severity was significantly decreased. In a one year long study at 600mg twice per day it showed it significantly improved lung function in COPD patients.

NAC is also believed to help increase immune function by restoration of natural killer cell functions. Further in a test tube study, NAC hampered the influenza virus’s ability to replicate. Finally, since it regulates glutamate, an important neurotransmitter in your brain it is believed to potentially be helpful with many mental health disorders like OCD, Bipolar disorder, Schizophrenia and even Alzheimer’s disease. So I do think that this is another supplement that we should consider using. It has lots of potential and only minimal side effects.

Lets revisit vitamin D as new information has been released.

A new report in Ireland released about a week ago reviewing multiple studies has some new information on vitamin D in COVID-19. This changes some of the things we have said before. I copied this paragraph as I think it is important. Note that while it makes cytokines in number 4 like we talked about previously. However,in number 5 we see that it decreases the production of pro-inflammatory molecules. Then number 6 showing this may actually help with cytokine storm unlike we previously suspected so this is very good news.

“4. Experiments and research has shown that vitamin D can alter the immune system response through its influence on the production and manufacturing of immune molecules known as cytokines (5). Vitamin D has been shown to help signal the increased production of ant-inflammatory molecules and decrease the production of pro-inflammatory molecules (6,7). This switch in immune response in theory may have some potential benefit in cases of ‘cytokine storm’ – a massive release of proinflammation (which has been observed in those infected with COVID (8)) which can cause acute respiratory distress syndrome (9). Importantly, in a large cross-sectional clinical trial (n = 18,883) the risk of respiratory infection increased with lower blood vitamin D levels and the effect was even stronger in those with underlying lung conditions”

The conclusion “Our people aged 70 and over and we must use all available tools to facilitate the reduction and transmission of COVD-19. Vitamin D is a potent immune modifying micronutrient and if vitamin D status is SUFFICIENT, it could benefit vulnerable adults in particular those 70+ years and older during the COVID-19 outbreak.”


496 posted on 04/23/2020 10:26:57 AM PDT by RummyChick ( Yeah, it's Daily Mail. So what.)
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To: PA Engineer

see 496


497 posted on 04/23/2020 10:38:46 AM PDT by Black Agnes
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To: RummyChick

498 posted on 04/23/2020 10:43:28 AM PDT by RummyChick ( Yeah, it's Daily Mail. So what.)
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To: RummyChick
We are using NAC in our research specifically because it is the feedstock for cysteine in the sulfur cycle. NAC is critical for one side of the cycle for production of glutathione and then glutathione peroxidase. This is one of three different pathways for the production of reactive oxygen species (ROS) scavengers. The other two are cysteamine and hypotaurine.

I posted a couple articles back at the beginning of this on NAC. It has been used for treatment of ventilator dependent patients suffering cytokine storms. The dose was quite high (IV). The best I can tell those studies had not been followed up on. That is very typical of medical research.

My wife and I practice what our findings show. We take NAC daily as well as pantehtine. Pantethine is the disulfide bond of pantetheine (NOT B5). This converts (safely) to cysteamine and then hypotaurine. We also add taurine to our daily regiment. Taurine is not an ROS scavenger, however it is critical for muscle related metabolism. Taurine is produced down stream of hypotaurine.

Whole eggs are a useful food for increasing cysteine pools.

JM2C. YMMV.
513 posted on 04/23/2020 11:41:41 AM PDT by PA Engineer (Liberate America from the Occupation Media.)
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