STUDY
Antibody Points to Possible Weak Spot on Novel Coronavirus
Other researchers had shown previously that CR3022 cross-reacts with the novel coronavirus, although the antibody doesn’t bind tightly enough to neutralize and stop it from infecting cells. So, Wilson’s team went to work to learn precisely where the antibody attaches ..
..A key finding in the new paper is that the antibody binds a highly similar site on both the SARS and novel coronaviruses. Those sites differ in each virus by just four amino acids,..
Intriguingly, the antibody binds to a spot on the novel coronavirus that is usually hidden, except for when virus shapeshifts its structure in order to infect a cell...
https://directorsblog.nih.gov/2020/04/14/antibody-points-to-possible-weak-spot-on-novel-coronavirus/
this commentary is a week old and may have already been posted but I thought the shapeshifted access point important.
I don’t know how many people listened to the hour long ‘musical’ that engineers turned the viral code into. But what if that ‘music’ can help us find that shapeshifting point? - maybe even just before or just after the jarring ‘hammering’ heard in the middle of the transcribed code?
DATA, DATA and more DATA
A 25 March paper in JAMA Cardiology documented heart damage in nearly 20% of patients... In another Wuhan study, 44% of 36 patients admitted to the ICU had arrhythmias...
The disruption seems to extend to the blood itself. Among 184 COVID-19 patients in a Dutch ICU, 38% had blood that clotted abnormally, and almost one-third already had clots, according to a 10 April paper in Thrombosis Research...
Mangalmurti says she has been “shocked by the fact that we don’t have a huge number of asthmatics” or patients with other respiratory diseases in HUP’s ICU. “It’s very striking to us that risk factors seem to be vascular: diabetes, obesity, age, hypertension.”...
...Viral particles were identified in electron micrographs of kidneys... But kidney injury may also be collateral damage. Ventilators boost the risk of kidney damage, as do antiviral compounds including remdesivir...
..Frontera has seen patients with the brain inflammation encephalitis, with seizures, and with a “sympathetic storm,” a hyperreaction of the sympathetic nervous system that causes seizurelike symptoms and is most common after a traumatic brain injury. Some people with COVID-19 briefly lose consciousness. Others have strokes. Many report losing their sense of smell. And Frontera and others wonder whether in some cases, infection depresses the brain stem reflex that senses oxygen starvation...
ACE2 receptors are present in the neural cortex and brain stem, says Robert Stevens, an intensive care physician at Johns Hopkins Medicine. But it’s not known under what circumstances the virus penetrates.... On 3 April, a case study in the International Journal of Infectious Diseases, from a team in Japan, reported traces of new coronavirus in the cerebrospinal fluid of a COVID-19 patient who developed meningitis and encephalitis...
longer read