Free Republic
Browse · Search
General/Chat
Topics · Post Article

To: RummyChick

Duffy Antigen is what I am thinking about with sickle cell


758 posted on 04/22/2020 6:54:50 AM PDT by RummyChick ( Yeah, it's Daily Mail. So what.)
[ Post Reply | Private Reply | To 757 | View Replies ]


To: RummyChick

Duffy antigen as it relates to HIV
https://retrovirology.biomedcentral.com/articles/10.1186/1742-4690-10-S1-O31

The African-specific DARC null allele increases risk of HIV infection.

HIV-2 strains but not HIV-1 strains utilised DARC as an entry co-receptor. However, HIV-1 could bind to DARC on red cells and be delivered to activated CD4+ T-cells resulting in subsequent infection. GWAS analysis confirmed the link between DARC null genotype and African benign neutropenia. The DARC null phenotype with African benign neutropenia resulted in low CCL5 plasma levels and increased the relative risk of HIV-1 infection approximately 3-fold.


759 posted on 04/22/2020 7:06:02 AM PDT by RummyChick ( Yeah, it's Daily Mail. So what.)
[ Post Reply | Private Reply | To 758 | View Replies ]

Free Republic
Browse · Search
General/Chat
Topics · Post Article


FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson