https://texags.com/forums/84/topics/3107246/replies/56392345
Marcus Aurelius8:13p, 4/16/20AG
We have one dose of toci left in pharmacy. No access to remdisivir. Told IL-6 inhibitors becoming unobtainable. 400 bed non-academic hospital. No clinical trials in hospital. Others experience? We have many hovering cytokine storm. Many will die until these drugs are available. I strongly think these will be shown to be efficacious with due science. Is it best to be admitted to an academic center if you’re really sick with COVID-19 until the research is completed? I’m beginning to think so. Food for thought.
more comments..and one I think very important if I have to go to a hospital in this time frame...go to an academic hospital
I do believe it is best to be admitted to an academic hospital based on what you said. I don’t believe this is fair but it is the sad reality. One thing to consider is some of the inclusion/exclusion criteria for these studies. A few of the criteria that I am aware of for the remdesivir study is no other concurrent treatment(no HCQ, IL 6 inhibit is), a positive test in the last 4 days, etc.
I do not think it is anemia. I think the virus messes with the rbcs ability to oxygenate. Which is also one of the theories behind hydroxychloroquine helping due to its effect on the porphyrin stuff in rbcs.
I might even consider drawing a couple of units off and transfusing a couple of healthy units. What can you lose?
Only thing that disputes this. Their Po2 is damn low. and correlates with O2 sat. i.e. no “rogue COVID-Hgb” species. But who the hell knows. Damn thing is not natural. WUHAN.
Spoke with Genentech rep. They are shipping toci on case by case basis. We have one dose. 2 pts teetering on storm. Haven’t pulled trigger. No access to sirulimab here.