Free Republic
Browse · Search
General/Chat
Topics · Post Article

To: Black Agnes

you might find this interesting. Maybe you recognize the names.

Crameri(Australian Bat Man with no current internet presence)
Shi ZL (China Bat Lady now missing)
Linfa Wang( Singapore Bat Man)

https://www.ncbi.nlm.nih.gov/pubmed/20335495

Identification of key amino acid residues required for horseshoe bat angiotensin-I converting enzyme 2 to function as a receptor for severe acute respiratory syndrome coronavirus.

Abstract
Angiotensin-I converting enzyme 2 (ACE2) is the receptor for severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV). A previous study indicated that ACE2 from a horseshoe bat, the host of a highly related SARS-like coronavirus, could not function as a receptor for SARS-CoV. Here, we demonstrate that a 3 aa change from SHE (aa 40-42) to FYQ was sufficient to convert the bat ACE2 into a fully functional receptor for SARS-CoV. We further demonstrate that an ACE2 molecule from a fruit bat, which contains the FYQ motif, was able to support SARS-CoV infection, indicating a potentially much wider host range for SARS-CoV-related viruses among different bat populations.


243 posted on 04/18/2020 7:24:27 PM PDT by RummyChick ( Yeah, it's Daily Mail. So what.)
[ Post Reply | Private Reply | To 241 | View Replies ]


To: RummyChick

Neat, thanks!


244 posted on 04/18/2020 7:26:35 PM PDT by Black Agnes
[ Post Reply | Private Reply | To 243 | View Replies ]

To: RummyChick

https://www.sciencedirect.com/science/article/pii/S0022175907003602

Determination and application of immunodominant regions of SARS coronavirus spike and nucleocapsid proteins recognized by sera from different animal species

MengYuaVickyStevensaJody D.BerrybGaryCrameriaJenniferMcEachernaChangchunTucZhengliShidGuodongLiangeHanaWeingartlbJaneCardosafBryan T.EatonaLin-FaWanga

Meng Yu
CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
National Centre for Foreign Animal Disease, CFIA, Winnipeg, Canada
Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China


246 posted on 04/18/2020 7:29:14 PM PDT by RummyChick ( Yeah, it's Daily Mail. So what.)
[ Post Reply | Private Reply | To 243 | View Replies ]

Free Republic
Browse · Search
General/Chat
Topics · Post Article


FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson