Posted on 03/19/2020 7:29:14 AM PDT by SeekAndFind
dont understand any of this article from 2014
but
Lethal mutagenesis has emerged as a novel potential therapeutic approach to treat viral infections
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204012/
MORE HERE:
Search for coronavirus cure boosted by go-ahead for Fujifilm’s Avigan
(EXCERPT)
TOKYO — Medical experts are turning to existing treatments for the flu, Ebola and other illnesses to save patients from the spreading pandemic amid a global push to develop a cure for the new coronavirus.
The Chinese government announced Tuesday that the influenza drug favipiravir, developed by a Fujifilm Holdings subsidiary and sold under the name Avigan, is effective against the coronavirus, based on a clinical trial of 200 patients.
Some Japanese doctors have also been treating coronavirus patients with Avigan. Tokyo has stockpiled enough of the drug to treat 2 million patients. “We have been asked by the government to consider increasing production,” Fujifilm said, though logistical hurdles are believed to stand in the way.
Avigan was approved to treat influenza in Japan in March 2014. Fujifilm signed a license agreement with China’s Zhejiang Hisun Pharmaceutical in 2016, and the latter is now gearing up to mass-produce the drug. Beijing is already recommending the drug to health care providers.
MORE HERE:
Search for coronavirus cure boosted by go-ahead for Fujifilm’s Avigan
(EXCERPT)
TOKYO — Medical experts are turning to existing treatments for the flu, Ebola and other illnesses to save patients from the spreading pandemic amid a global push to develop a cure for the new coronavirus.
The Chinese government announced Tuesday that the influenza drug favipiravir, developed by a Fujifilm Holdings subsidiary and sold under the name Avigan, is effective against the coronavirus, based on a clinical trial of 200 patients.
Some Japanese doctors have also been treating coronavirus patients with Avigan. Tokyo has stockpiled enough of the drug to treat 2 million patients. “We have been asked by the government to consider increasing production,” Fujifilm said, though logistical hurdles are believed to stand in the way.
Avigan was approved to treat influenza in Japan in March 2014. Fujifilm signed a license agreement with China’s Zhejiang Hisun Pharmaceutical in 2016, and the latter is now gearing up to mass-produce the drug. Beijing is already recommending the drug to health care providers.
per wiki
Approval status
In 2014, Japan approved Favipiravir for treating viral strains unresponsive to current antivirals.[18] Toyama Chemical initially hoped that Avigan would become a new influenza drug that could replace Tamiflu. However, animal experiments show the potential for teratogenic effects on fetuses, and the approval of production by The Ministry of Health, Labor and Welfare was greatly delayed and the production condition is limited only in an emergency in Japan.[19]
In March 2015, the US Food and Drug Administration completed a Phase III clinical trial studying the safety and efficacy of Favipiravir in the treatment of influenza.[20]
Yup. I’ve read a bunch of the NCBI reports.
Antiviral? Not a cure, but a treatment.
Before Wuhan hit
https://www.medscape.com/viewarticle/922729
Two Drugs Better Than One for Severe Influenza
This will never see the light of day on the Fox Business website.
All they want is doom, doom, and more doom.
from several years ago
MediVector Inc. has been awarded a maximum $9,135,695 modification to previously awarded contract HDTRA1-12-C-0031 for the capability to manufacture antiviral therapeutic Favipiravir in the U.S.
https://globalbiodefense.com/2016/08/11/favipiravir-medivector-dtra-jpm-mcs/
For the vast majority of current Coronavirus patients, who are either male or over age 60, that should not be a problem.
You can make a drug / vaccine that is:
- safe
- effective
- produced quickly
But you only get to choose two of the three.
so it appears this drug has been in the works for awhile
So, could Chinese have been working on the Cure...and the bioweapon...and it got accidentally released before they were ready.
Stocks haven’t fallen far enough yet.
RE: This will never see the light of day on the Fox Business website.
All they want is doom, doom, and more doom.
_______________________________________
Well, not all Fox is doom and gloom.
FOX NEWS actually featured an interview with Gregory Rigano, co -author of a study that shows COVID-19 patients who took hydroxy-chloroquine were free of the disease in 6 days.
SEE HERE:
Instead of concentrating on the new fangled therapeutics, we ought to be reaching for on-the shelf methods. I know big Pharma doesn’t want to hear that message, but things like chloroquine in combination with zinc or Z-pack need to be tried immediately. These combinations have a scientific basis to suggest they just might work.
I would suggest that you could choose "effective" and "quickly" from your list and get lucky to have a safe drug, but you would not be able to prove that without further, lengthier trials in humans.
Efficacious, quick and safe are mutually exclusive; proving that they're safe requires additional time.
RE: chloroquine in combination with zinc or Z-pack need to be tried immediately. These combinations have a scientific basis to suggest they just might work.
They should publish the protocol that worked in the study PRONTO even without FDA approval.
How large a dosage of chloroquine in combo with zinc should patients take, etc.
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