>>> Sean Lin, PhD in microbiology and former director of the Virology Laboratory at the former Walter Reed Army Institute in the United States, believes that it is extremely unusual for the amino acid sequences of the E proteins of Wuhan virus and Zhoushan virus to be 100% identical. Because E protein has an indispensable effect on the virus morphology, assembly, budding, and virus pathogenicity of β-type coronavirus. If the virus changes the host, many cytokines will change, and the E protein will necessarily have corresponding changes to adjust the virus synthesis and pathogenicity.
>>> He further pointed out: The genes of the E protein and the genes of the S protein are adjacent to each other. In the viral RNA replication process, these two genes also need to complete the production of subgenomic RNA (subgenomic RNA) to complete replication, which also involves similar Intracellular factors and viral RNA polymerase, so the error rate of gene replication during this process is also similar. Therefore, there is no reason that during the natural viral replication process, the S protein has various mutations, while the E protein remains completely similar with the entire host transformed. This is basically impossible to happen naturally.
This is basically impossible to happen naturally.
This is basically impossible to happen naturally.
DAFUQ. Confirms what I was thinking but on different grounds.