It has been reported that SARS-CoV directly infects monocytes, macrophages and T lymphocytes in human.17 The PLD may also be secondary to activation of T lymphocytes.18
Our findings showed that CD4 and CD8 T lymphocytes have significant difference (p < 0.01) between mild (Non-ICU) and severe or critical (ICU) cases without glucocorticoid treatment indicating COVID-19 directly effected on immune system is possible.
COVID-19 has spread rapidly since it was first identified in Wuhan and has been shown to have a wide spectrum of severity as SARS-CoV-2 binds to ACE2 receptors in 10-20 fold higher affinity than SARS-CoV binds to the same receptors.7,19 The report shows SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2.8 Therefore, it is necessary to further study whether lymphocytes have ACE2 receptor and TMPRSS2 expression during the developmental stage since the PLD exists. A SARS-CoV-2 RT-PCR assay for lymphocyte subsets in severe or critical cases should be followed up. Our findings also suggest that lymphocyte subsets should be analyzed at admission immediately no matter how COVID-19 affected lymphocytes through directly or indirectly. When patients are confirmed as COVID-19, clinicians should order tests for lymphocyte subsets in order to intervene early in the consequences of the PLD.
Conclusions
...The mortality rate is 4.6% in Wuhan, 1.9% in Beijing, and 0.9% in Shanghai. Our findings showed that the levels of lymphocytes were 0.8 (IQR, 0.6-1.1) 109/L in Wuhan, 1.0 (IQR, 0.7-1.4) 109/L in Beijing, and 1.1 (IQR, 0.8-1.5) 109/L in Shanghai before admission to hospitals, respectively, indicating that cellular immune function might relate to the mortality.
NOT PEER REVIEWED:
https://www.medrxiv.org/content/10.1101/2020.03.08.20031229v1.full.pdf
Herschel Smith Katybuzz • 19 minutes ago
Oh, it was engineered alright. At UNC-Chapel Hill, with the assistance of a Chi-com.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797993/
https://www.sciencedaily.com/releases/2015/11/151110115711.htm
Note the wording; " ...we generated and characterized a chimeric virus." She didn't just study it, she generated it.
Next up, I'll leave you to do the research about study of this virus in Canada by the same Chinese lady, and the fact that she had her badge pulled and was ejected from the country, with the Canadian police still in the active investigation mode.
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