Posted on 01/15/2020 8:16:27 PM PST by ConservativeMind
A cholesterol-lowering drug reduced the enlarged prostates of hamsters to the same extent as a drug commonly used to treat benign prostatic hyperplasia (BPH), report researchers at Children's Hospital Boston and their colleagues in the October issue of the Journal of Urology. Together, the drugs worked even better.
"We don't know the mechanism, but the results suggest to us that lowering cholesterol has the potential to reduce BPH in men," says senior author Keith Solomon, PhD, a biochemist, and member of the departments of Orthopaedic Surgery and Urology at Children's. "This brings up the possibility that other cholesterol lowering therapies, including exercise and diet, may prevent BPH from developing."
Led by first author Kristine Pelton, the team tested ezetimibe, an FDA-approved hypercholesterolemic drug (Zetia; Merck) against finasteride (Proscar, Propecia; Merck), a standard therapy for the treatment of BPH. Ezetimibe reduced prostatic enlargement in aged hamsters as effectively as finasteride and combining the two drugs worked better than either one alone.
In an unexpected finding, pathologist and co-author Dolores Di Vizio, MD, PhD, observed that finasteride caused atrophy of the hamster prostate while ezetimibe did not. "These findings provide strong evidence that the cholesterol-lowering drug inhibits BPH by a novel mechanism," said co-author Michael R. Freeman, PhD, professor of Surgery and director of urologic research at Children's Hospital.
The potentially therapeutic effect of cholesterol-lowering on enlarged prostates was pioneered 40 years earlier by co-author Carl Schaffner, PhD, professor emeritus at Rutgers University, who reported similar results in pre-clinical models using a different cholesterol-lowering drug.
(Excerpt) Read more at sciencedaily.com ...
. No need for drugs. A whole food, plant-based diet can accomplish both the lowering of cholesterol and treating the enlarged prostate.
https://nutritionfacts.org/2013/02/05/treating-an-enlarged-prostate-with-diet/
What about ugly and ordinary looking hamsters?
Now don’t get me wrong, I had to deal with prostate cancer 2 years ago. My question would be, how much pound for pound would a person have to take compared to the lab animal? I had cancer, an enlargement issue wasn’t my problem. The question is just my curiosity.
Richard Gere is PLEASED!
And I have been on Lipitor/Generic since it was invented (almost). Maybe that is a factor for not having prostate symptoms.
LOL!
ROFL
The potentially therapeutic effect of cholesterol-lowering on enlarged prostates was pioneered 40 years earlier by co-author Carl Schaffner, PhD, professor emeritus at Rutgers University, who reported similar results in pre-clinical models using a different cholesterol-lowering drug.
...
So they are copying work from 40 years ago. And why is a children’s hospital researching prostate enlargement?
“Cholesterol-lowering drug shrinks enlarged prostates in hamster model”
I’ve never had a hot-looking hamster with an enlarged prostrate, but I will keep this in mind for the future.
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