I wonder if drugs that selectively target the other opioid receptors would be effective for pain in people like me, for whom opioids give no relief. They sure cause plenty of side effects, though.
Eventually we will have designer drugs that target specific pain pathways, not just a blanket coverage like opioids. It’ll be like a laser guided bomb instead of a carpet bomb.............
Up with DOP, down with MOP!
Many have found pain relief from kratom. For me, it mimics the euphoria and energy provided by opiates, but since I don’t have pain, I don’t know about those effects. I believe it hits a kappa or mu receptor, I forget which, and causes no respiratory depression. Of course, it is addictive as well. It’s illegal in some states. Immodium hits another opiate receptor. I’ve read it can ameliorate withdrawal symptoms of opiates, but I don’t think it has any pain relieving qualities. Although 90% of online info on kratom is worthless, you might find some gems. But if opiates or opioids don’t help, conceivably kratom may not, either.