I take two BP meds.
One - the “water pill” I take in the morning between 8 and 9.
The second med I take in two doses, one between 11AM and 12PM and the second dose between 11PM and midnight (roughly noon and bedtime). I have found the second pill taken twice in a 24 hour period at the dosage I use works better than did a double dose taken once a day.
Splitting it up and taking half as much twice a day makes for a more steady amount of that BP med in the blood stream than taking it all at once. At the dosage I take it is known to lose it’s positive impact in less than 24 hours, but still has sufficient impact at 12 hours in.
I did not know any rationale for setting up my 12 to 12 split between those two doses. I did it because one at noon and one at bedtime seemed practical to me.
I’ve got a low dose of the, uh, lisinopril? and the water pill is also in there.
A symbiotic relationship has been found between diuretics (such as HCTZ) and ACE inhibitors (such as Lisinopril). Each have their own contribution to lowering blood pressure, but when taken together, it is much greater than the sum of the components. Researchers do not yet understand how the combination works, they just know that it does.