A symbiotic relationship has been found between diuretics (such as HCTZ) and ACE inhibitors (such as Lisinopril). Each have their own contribution to lowering blood pressure, but when taken together, it is much greater than the sum of the components. Researchers do not yet understand how the combination works, they just know that it does.
“Researchers do not yet understand how the combination works, they just know that it does.”
I take a pain med - gabapentin - that they (all the research) says the same thing about. Gaba leaves the body as it goes in, not broken down, which means it does not interact with other chemicals. Yet something about its mere presence in the chemical soup of the brain cells causes a change in the response we know as pain. How, they don’t know, for sure. Their best guess is that it’s presence alters the electrical activity in the string of chemical-electrical signals in brain and nerve cells.
Its first use was with epileptics as an anticonvulsant - helped prevent epilieptic siezures.