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Most drugs are detoxed from the body through liver enzymes. It’s what creates the half life. Specifically, cytochrome p450 enzymes and depending upon the drug(or hormone) CYP3A4 is the most utilized.

It functions in the mitochondria or endoplasmic reticulum of most cells in the body.

TOO MANY DRUGS AND/OR CERTAIN FOODS CREATES CYP450 DEFICIENCY AND THE BODY BECOMES TOXIC.

Some drugs/herbs act as CYP 450 inhibitors.

Here are a few cut & paste notes FYI:

Saint-John’s wort, a common herbal remedy induces CYP3A4, but also inhibits CYP1A1, CYP1B1.

Tobacco smoking induces CYP1A2 (example CYP1A2 substrates are clozapine, olanzapine, and fluvoxamine)

At relatively high concentrations, starfruit juice has also been shown to inhibit CYP2A6 and other CYPs.

Watercress is also a known inhibitor of the cytochrome P450 CYP2E1, which may result in altered drug metabolism for individuals on certain medications (e.g., chlorzoxazone).

Tributyltin has been found to inhibit the function of cytochrome P450, leading to masculinization of mollusks.

Goldenseal, with its two notable alkaloids berberine and hydrastine, has been shown to alter P450-marker enzymatic activities (involving CYP2C9, CYP2D6, and CYP3A4).

At age 95 my mother was in a nursing home in extreme pain. She was bedridden and wanted to die.

I brought her to my house and detoxed her from alk her meds.. first Tramadol, then the atypical antipsychotic, then through many others and finally her Verapamil. It took 3 weeks before I could teach her how to walk again, holding her and her walker from behind, steering her till she learned the house (she was also blind for the second half her life).

Within a few weeks she was walking normally and her pain was gone. She could go to the bathroom herself, feed herself and shower with some help.

At 6 months I took her to a new Dr. who was the chair of geriatric medicine at the med school. He examined her, ran some blood tests and said she was fine. His exact words were that by her body chemistry “she could be in her twenties.”

I told him that was impossible as she has had severe kidney disease for 40 years. He showed me it was GONE. Her BUN/creatinine levels were normal.

For three years she functioned pretty well with a quality of life and passed just short of 98. The detox did not stop the dementia, but it slowed its progress.

She decided it was time to die and just stopped eating. After 2 weeks she stopped drinking or eating and passed a week later.

The one unusual observation I had was that no rigormortus set in after she passed... for at least the 12 hrs later when I put a long sleeve blouse and slacks on her to remove her body for services.

Managing liver enzymes was the key to her detox.