I viewed an accurate reenactment on ID of two neighbors( a man and a women ) rushing a guy with a 9mm. There were many eye witnesses. The woman was hit 6 times in the legs and torso and kept running at the pistol shooter. The neighbors thought he was missing or shooting blanks at her. In the witnesses own words the bullets had no visible effect on her. The man was the same. He was hit 7 times, mostly in the torso, and they had NO immediate effect on him what so ever.
There are several documented cases of LEO shootouts were a bad guy was shot in the heart with a 45 and continued to shoot back for over 40 seconds until they bleed out. The only way to “take someone out” with one shot is to hit the spinal cord, brain stem or brain. And a 9 or 45 are equally effective in that regard.