There are several documented cases of LEO shootouts were a bad guy was shot in the heart with a 45 and continued to shoot back for over 40 seconds until they bleed out. The only way to “take someone out” with one shot is to hit the spinal cord, brain stem or brain. And a 9 or 45 are equally effective in that regard.
"General Leonard Wood stated what he thought was obvious to anyone paying attention, ‘It is thought that the .45 caliber revolver [meaning Constabulary Model 1902] is the one that should be issued to troops throughout the Army . . . Instances have repeatedly been reported during the past year where natives have been shot through and through several times with a .38 caliber revolver, and have come on, cutting up the unfortunate individual armed with it . . . The .45 caliber revolver stops a man on his tracks, usually knocking him down . . . “"