Posted on 07/03/2019 6:48:47 PM PDT by BenLurkin
Cannabis suppositories have grown in popularity, but how and to what extent they actually work remains a mystery. With contradictory claims from proponents and skeptics regarding the rectal bioavailability of THC, intoxication (or lack thereof), and alleviation of symptoms of difficult-to-treat diseases, its time to get a grip on what we really know about this method of administering cannabis.
Clinical research on cannabis suppositories is still limited. Much of the available data pertains to experiments conducted on animals, not on people who actually use suppositories. Despite the distinct lack of clinical studies, anecdotal accounts from patients are often very positive. The overwhelming majority of patient reports have one thing in common: a lack of intoxication thats typically caused by smoking or ingesting THC-rich cannabis.
The absence of a head high would seem to indicate that a suppository does not distribute a systemic dose of cannabis which corroborates initial research findings about limited bioavailability. This suggests that a suppository acts more like a topical with a local effect, rather than a transdermal patch which disseminates medicine systemically through the bloodstream.
Why suppositories?
Rectal and vaginal suppositories have both been used to deliver medicine to patients for decades. The pelvic region houses a matrix of nerves that travel to the legs and up the spine, and the colon contains cannabinoid receptors (CB1 and CB2), which mediate many of THCs effects.
Generally, cannabis suppositories are made by combining cannabis-infused oils in a carrier oil that hardens at low temperatures. Rectal administration of cannabis oil may activate the cannabinoid receptors located there, which could be beneficial for local conditions like hemorrhoids or acute inflammation [6]. The rectum also contains a number of key veins that deliver blood to the entire body, but it doesnt appear that suppositories facilitate cannabinoid absorption into the bloodstream.
(Excerpt) Read more at projectcbd.org ...
Just ewww.
This pill is too big and hard to swallow, tastes horrible, and for all the good it does, I might as well stick it up my a**.
Probably better than a beer enema.
LOL!!! Thread winner right there!
Just a little pinch between your cheeks and gums...
Don’t Bogart that joint my friend.
Damn near...wait, what?
Taking it in the top end wasn’t enough, now they want to stuff it in the southern end. Sounds dumb.
Do it analy, means it doesnt interfere with eating Cheetos and tacos.
Only if they stick all of it...
Yeah for sure.
I forgot the numbers. 3 bags Cheetos, 27 tacos, and a small coke. Also two pair of latex glove, 1 pair for insertion and the other to keep your underwear from getting the yellow cheese stains and taco sauce on them.
As long as you dont try to smoke them
-PJ
There are lots of other ways to please the rectum.
Aaannnnd, once again, I came for the comments.
Apparently coffee enemas work.
“The best part of waking up is Folgers up your butt.”
Yeah, Ineffective, too. I might as well have just shoved them up my a$$!
My understanding is that cannabis needs to be heated in order to make you high
How the heck do you keep it lit?
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