Not to push Carl Sagan, but he did surmise that the distances were far to great. Interdimentional makes more sense even if it is harder to grasp
Thus, if an alien was traveling at light speed then hitting a tiny speck of something could be tragic. Compound that potential across scores of light years and, with our current technology, light speed travel is almost impossible. There has GOT to be a bit of rock somewhere between here and there, and if you hit it then KABLOOIE!!
The problem is we dont know what we dont know. Concluding that space travel from the stars is unlikely because of the great distances involved reminds me of the 19th Century scientists who opined that the Sun was less than 5,000 years old because thats how long a lump of coal that size could burn. Of course, they new nothing of nuclear physics and coal was the only source of combustion they could imagine which might fuel the Sun.