Just about the same age John Ritter passed away at but JR had an aortic aneurysm rupture. Uncontrolled hypertension can lead to heart attacks, strokes and aneurysms. Could have been a factor regarding Luke Perry.
He was supposedly a spokesman for colonoscopies (having had one about 4 years ago that uncovered some stuff) so I don’t think he was unchecked that way.
He definitely had something seriously wrong, lurking underneath the surface. I’m surprised his dr didn’t catch and get him on meds/or refer him to a cardiologist.