I have at least two ancestors who came over on the Mayflower, and one who was in Jamestown, my last name traces to a settler in New Netherlands in 1664, but none of those lines seem to have married aboriginal Americans. It might be fun just to try it out. My Nephew took the test, and the only interesting thing was Scandinavian/Danish. His father was Danish, so that doesn’t affect me.
I call a lot of people newcomers, since every branch of my family traces back to people who arrived in the 1600s (Massachusetts Bay and Connecticut colonies) and their American ancestors usually dont go back very far. But your roots predate mine! Wow! You and I might be related, too.