If this is a fairly recent developing condition, it may be the brain’s response to one of the many strep viruses. A friend’s son had a very sudden mental-state change that mystified them and all doctors. Previously, the young boy was very well behaved, and quite intelligent. He began to lash out at sibling and school mates, and even at parents and teachers. He would threaten to kill them, and would rage uncontroably. The standard response from doctors was drugs normally prescribed to over-active kids. My friend was not settling for doping her son up. She read and learned about the myths of the brain/blood barrier, and recent discoveries of strep viruses, and how they can stay resident in the child’s brain, causing what normally would have been diagnosed as psychiatric condition. She strongly urged he doctor to do blood panels and tests, specifically screening for strep viruses, but not isolated to that alone. The doctor complied, and they discovered two things. The strep virus was still present from a previous flu. The boy was also found to have PANDA/PANS, which somehow predisposed him to reacting to strep viruses in a behavioral way. I will prompt my friend, and find out more.
PANDA syndrome was my first thought as well. Have a thorough workup by a rheumatologist, as autoimmune problems can contribute to psychological issues.
Another thought could be an extreme reaction to hormonal imbalance of some sort, such as thyroid issues.
Very interesting developments.
I'm an EMT and have found that many psychological issues have a viral or bacteriological start.
First thing I look for in a psych issue.
And don't forget diabetes!