Taking out Saddam was not the mistake. Taking out Saddam and not following through with a post WWII European occupation for the next 25 years was the mistake. And apparently we no longer have the fortitude for that.
Changing the Mideast culture to one that is western friendly will take at least a generation. Obama cut and ran the second he took office. He left the void that Tehran and ISIS have filled. As long as we have this wishy washy electorate, we cant make any long term commitments that allies can rely on. The best we can do is contain the problem in the ME.
Muslims have been fighting each other for centuries. Their cultures are incompatible with our Constitution. Our interference in country after country has only made things worse. We have no right to force any country to be like us.