Well, I don't want to give you advice that doesn't work in your particular situation. Without knowing a lot of the details about your particular system, and what "clean-up" tool(s) or commands you want to use, I'm leery of saying "Yeah, it's okay, full steam ahead". Every system and situation is a little different.
What tool are you planning to use to delete stuff?
Disk Cleanup.
I delete temp files and my recycle bin.
Just seems like whatever is in there takes up over 1GB of space.
I use my computer (Win 10) for personal use and really only access the internet and do some spreadsheets using Excel.