I'm almost ascared to tells ya, (unless you already know), but the Twinkie factory is now hotel/condo.
[I grew up less than a mile from it too, back when there was a single swinging yellow flashing light above the intersection of Route 9 and Speen Street. Natick Drive In and sewer fields]
Do you remember the aroma that used to come from that place when you went into the Sears parking lot? Heeeeeavenly.