My family used to live out near the canyons. We lost several cats presumably to the coyotes; only one, Tina, ever made it to old age. There was also owls in our area -- I heard hooting late at night -- but I doubt they were the culprits. I once saw a pack of coyotes scurrying into the bushes not far from our home.
In the end, we stopped owning cats; there was no point.
My daughter moved to suburban Denver at the beginning of the year and she was very surprised to see no cats at all in her neighborhood. She spotted the very rare one snoozing by a window and looking out. Her friends at school explained to her that most of them don’t survive long if they get out due to the coyotes. That’s a far cry from the burbs in our area where she grew up and you can generally let your cats outside. She got a dog instead of a cat which has probably turned out even better for her.