We've modified wheat.
We've modified livestock.
We've done amazing things with modern medicine.
As to where we should stop that train, I think we're on our own.
Yeah, There are advances that I’m not comfortable with too, but most I have no religious objection to, like gmo food.
I’ve got mixed feelings about gmo food. It may help alleviate hunger, a very positive thing. But do we really understand all the ramifications? Did it cause Morgellon’s disease? We are introducing new things into the human diet. But then who can argue against bacon flavored kale?
We will have to confront a Ship of Theseus paradox (See also Identity over Time for a more thorough discussion).
At what point does the soul leave the body or body leave the soul when the skin has been replaced by radiation-proof cladding and the brain is a silicon-based CPU running neural net algorithms?
What happens to the person's soul when his consciousness is uploaded into the cloud and then copied thousands of times later to be downloaded into a slew of various bodies?
What happens when a person can be a man on Mondays, a woman on Tuesdays, neutered on Wednesdays, and hermaphroditic on the weekends?
Will these highly altered "humans" have souls?