The Food and Drug Administration is recommending that health professionals stop prescribing combination drugs that contain more than 325 milligrams of acetaminophen per tablet, capsule, or other dosage unit, citing the risk of possible liver damage.
The agency said in a statement Tuesday that limiting the amount of acetaminophen per dosage unit will reduce the risk of severe liver damage from an inadvertent acetaminophen overdose, which can lead to liver failure, liver transplant, and death. ...-
http://www.foxnews.com/health/2014/01/15/fda-issues-warning-on-drugs-containing-acetaminophen/
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Combining acetaminophen pain relievers, which include Tylenol, and even light amounts of alcohol can more than double the risk of kidney disease, new research suggests.
Taking the recommended dose of acetaminophen, combined with a small to moderate amount of alcohol, produces a 123 percent increased risk of kidney disease, according to a new preliminary study. ...
-http://www.webmd.com/mental-health/addiction/news/20131104/tylenol-and-alcohol-a-bad-mix-study-suggests
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... Even when taken at recommended doses, acetaminophen, the primary active ingredient in Tylenol, can cause major damage to the liver, potentially leading to liver failure and even death. In fact, acetaminophen is currently the leading cause of sudden liver failure in the U.S., as its toxic metabolites have been shown to kill liver cells. The drug is so toxic that as many as 80,000 people are rushed to the emergency room annually due to acetaminophen poisoning, and another 500-or-so end up dead from liver failure. ...
-http://www.naturalnews.com/043155_Tylenol_liver_damage_warning_label.html#ixzz3cz9xt7SF
I have had a difficult time finding 325s for a while and that is the dosing I like to use.