Pharmacokinetics[edit]
While 80% of flunitrazepam that is taken orally is absorbed, bioavailability in suppository form is closer to 50%.[11]
Flunitrazepam has a long half-life of 18–26 hours, which means that flunitrazepam’s effects after nighttime administration persist throughout the next day.[12] Residual “hangover” effects after nighttime administration of flunitrazepam, such as sleepiness and impaired psychomotor and cognitive functions, may persist into the next day. This may impair the ability of users to drive safely, and increase risks of falls and hip fractures.[13]
Flunitrazepam is lipophilic and is metabolised hepatically via oxidative pathways. The enzyme CYP3A4 is the main enzyme in its phase 1 metabolism in human liver microsomes.[14]
https://en.wikipedia.org/wiki/Flunitrazepam
That is the name for Rohypnol, which is in the government fact sheet that I linked to. However, for some reason that page comes up as unavailable right now. But I had no trouble saving it at archive.org so apparently it is available after all. It is saved at https://web.archive.org/web/20141219013933/http://womenshealth.gov/publications/our-publications/fact-sheet/date-rape-drugs.html?from=AtoZ
Here is the description that the government gives for Rohypnol (notice that the effects can last for several hours. Not 2 days. From what I’ve read if a person was out for 2 days it’s probably a severe overdose - in which case the gal is lucky to even be alive. And if she was passed out for 2 days and nobody in her life noticed and she didn’t go to the doctor immediately afterwards to find out what had just happened, then somebody is crazy. Anyway, here’s what the government publication says:
Rohypnol
The effects of Rohypnol can be felt within 30 minutes of being drugged and can last for several hours. If you are drugged, you might look and act like someone who is drunk. You might have trouble standing. Your speech might be slurred. Or you might pass out. Rohypnol can cause these problems:
Muscle relaxation or loss of muscle control
Difficulty with motor movements
Drunk feeling
Problems talking
Nausea
Can’t remember what happened while drugged
Loss of consciousness (black out)
Confusion
Problems seeing
Dizziness
Sleepiness
Lower blood pressure
Stomach problems
Death