Guede is obviously involved and I believe the evidence indicates that he didn't act alone.
That being said, I don't know whether Knox was involved.
I do know that the strongest Knox advocates ignore the fact that there was some forensic and circumstantial evidence against her. It was fair to find her not guilty in the face of the evidence. It's not fair to blindly suggest it didn't exist.
She created multiple lies about what happened that night. One of those lies was that she was there when the murder and sexual assault happened when another man did it, who we now know was completely involved.