One needs to be trained on the specific
firearm before loading or carrying.
Of course one should check the particular gun you have but all late model Rugers and even early models which have been changed are safe.
I think just about all imported six shooters have some type of safety device which you should get to understand how it works.
I don’t know of any modern double action revolver which is unsafe to carry with all chambers loaded. If there is one it is probably a very oddball.