Of course one should check the particular gun you have but all late model Rugers and even early models which have been changed are safe.
I think just about all imported six shooters have some type of safety device which you should get to understand how it works.
I don’t know of any modern double action revolver which is unsafe to carry with all chambers loaded. If there is one it is probably a very oddball.
My point was don't consider some yahoo on youtube as a trainer.