“I wonder if Israel’s “defense systems” include using nukes”
Yes, it is called their “Sampson Option”. Netanyahu and leaders before him make it plain if the life of Israel is severely threatened, they will use the Sampson Option. Sampson had lost his strength due to his hair being cut. He stood between the pillars holding up the building and prayed for strength to take those pillars down. He pulled them down and he died, too. The analogy is Samson took the enemy down before he died, too, so Israel would destroy its vile enemy even if they died in the process, too.
Yes, I know about him, and the jawbone of an a$$. I don't think the Masada option is on the table anymore.