Great, another study that puts us closer to healthy, good looking mice.
The biggest diet bugaboo is trying TOO hard, skipping meals in the interest of skipping calories. Alas Mr. Metabolism is all over the situation and slows down and it backfires. Better to eat three square but moderate meals and keep the pattern up for weeks or years if need be until the desired weight is reached.
Hallelujah, they cried, we've found the cure for obesity! Then they found that obese humans had very high levels of leptin - and that the problem wasn't that obese humans weren't producing it, but that they'd become resistant to its signaling.
And they were amazed. In just the same way that they were amazed when they learned how to measure insulin levels in humans, and discovered that type 2 diabetics. instead of having very low levels of insulin, like type 1 diabetics, as they'd always assumed, actually had very high levels of insulin, and were resistant to its effects.
I'd be not at all surprised if when they try this in humans they find out it doesn't work out the way they expect it to.
Eat less and exercise more.
Occam’s razor applies.
Good. I’ll get right on making the complementary small silencing RNA to turn off that microRNA-155. It shouldn’t be that hard, give me a week or so to make it, and another 15 years for the clinical trials...
Rats get all the best diets and fat burning drugs. All humans get are maybes and promises that never seem to happen.
BTTT