The question is not just how they fit your hands when you are drawing or aiming, I think it’s also how they feel as they are discharged. 1911s are weighty and a little front-heavy, which tends to help with keeping the big .45 on target. There are 1911 variations chambered for 9mm, and I have never fired one, but I doubt I would have much use for them. In the 9mm realm one doesn’t need so much weight up front. That said, for personal protection and home defense, the revolver really is a perfect weapon. It is inherently safe and can sleep loaded for months or years... And in a panic in the dark where milliseconds count you won’t need to fiddle with a safety. And - should six .357 rounds fail to eliminate your immediate threat, never mind higher capacity: you probably shouldn’t own a handgun anyway!
I have a little .357 Ruger six shooter for that very reason. Also terrific for conceal carry, and to keep in the car.
Depends on your situation. Against a single attacker, yes. If you're trying to get out of a riot, the more rounds the better.
If someone is going years without practicing or exercising their choice of personal protection, they may find their own skill sub-par to the requirements of the situation.
should six .357 rounds fail to eliminate your immediate threat...
Then perhaps your threat didn't enter your premises alone, compounded problem if you didn't practice your aim and response for years.