“By cells growing - do you mean it stops globules of fat from acreting? Fat comes in molecules rather than cells, so globules of fat acrete rather than grow. If so, then it basically has the same effect as paint thinner does to paint?”
No.
Resveratrol downregulates the secretion and gene expression of adipokines (IL6, IL8 and monocyte chemoattractant protein 1) and thereby decreases fat storage.
Fischer-Posovszky P, Kukulus V, Tews D, Unterkircher T, Debatin KM, Fulda S, Wabitsch M.
Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner. Am J Clin Nutr. 2010 Jul;92(1):5-15. Epub 2010 May 12
To summarize, fat cells do not take in the fat molecules and don’t grow independantly from carbohydrates. The fat molecules are used for something else (energy) or removed from your body (poop).
The take away is reservtol makes it much harder to GET FAT.
OK thanks.
Your explanation was very helpful - my last response didn’t do it justice.
Jewbacca, thanks for getting the title of the citation. If you enclose a title within quotation marks, you can get the abstract, if there is one, and sometimes the original article, if it's open access, i.e. a FReebie.
"Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner."
Hormetic response of resveratrol against cardioprotection
The last link goes to the abstract. The abstract links a PDF FReebie. Happy New Year!
FReepmail me if you want on or off the diabetes or immunology ping lists.
P.S. It's helpful to remember what's happening intracellularly as opposed to extracellularly. When your doc does a lipid profile, the last time that I checked, the lab measures total cholesterol, HDL-cholesterol and serum triglycerides. (The "bad" LDL-cholesterol was calculated from from those fractions.) The serum triglycerides are in equilibrium between the blood level and the amount in adipocytes. In the blood, serum triglycerides are in equilibrium between the three free fatty acids and the glycerol spine of a triglyceride molecule. In human hearts, and probably most mammals, the mitochondria can use free fatty acids, as well as carbohydrates, to generate Adenosine TriPhosphate, ATP, the currency of energy at the cellular level from aerobic or anaerobic respiration.
P.P.S. Any corrections or updates are always appreciated.