If the locations fell right, I bet Boise could. If the two toughest games happened to fall in Boise one year, I do think they could run the tables. Historically, that kind of home/away luck has been needed for any SEC team to run the tables completely. Even this year, the winner will likely have a conference loss (I fully expect Bama to beat Auburn).
More than that, I am absolutely certain Boise could run the tables in the Big Ten more than one year.