I don't know that I'd agree with that. Europe went through the same thing as the more advanced civilizations basically wiped out the indigenous barbarous people (Caesar against the Gauls, Charlemagne's conquests, etc). The American treatment of the Indians and the American institution of slavery are mentioned so often because it gives America haters (both here an abroad) an excuse to spit on America.
Liberals will always make it out that whites in North America took immediate, constant and gratuitously unfair advantage of Native Americans.
That happened… but NOT immediately, invariably or permanently as Liberals like to claim!
Also, to the extent that Native Americans became involved with the ‘politics’ of the colonials and the crown, they exacerbated the situation.
But, I don’t honestly know how they could have avoided it. Native Americans wanted trade (weapons, especially) with whites and compromised themselves from that point on.