Since the drug trade is an international war against America involving dozens of nations, it would be pretty hard to deal with it on a purely state by state basis. Nebraska might like Afghan Opium and Cannabis products but them dealing directly with Afghanistan or for Colombian Cocaine supplies would sure complicate things.
My personal opinion is that I'm willing to keep drug prohibition in effect when approved by state electorates, but all the police state accretions of the last thirty years (no knock raids, asset forfeiture) have to go.