My personal opinion is that I'm willing to keep drug prohibition in effect when approved by state electorates, but all the police state accretions of the last thirty years (no knock raids, asset forfeiture) have to go.
Well if we can get Afghan Opium into Nebraska, how could it possibly interfere with other states, or our foreign policy goals.
If Louisiana legalizes it, then the Taliban could ship it to New Orleans and it could be disseminated to Louisianans and delivered by air cargo for dissemination to Nebraskans.
Legalized Opium and reducing the size of government seem like conflicts to me.