I never liked that taste of it, so I never ingested enough to get a reaction. I do like Splenda. I even use it when I bake.
Splenda is revolting. Try Stevia. But don't use too much, or it tastes bitter. You have to re-educate your taste buds, so that you can detect more subtle degrees of sweetness. I sometimes like to have a super sweet cup of coffee--like you might find in Mexico. So I add about 4 drops of Stevia and then about 2 tsp of sugar. It's a great combination.