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Low vitamin D levels are related to ms brain atrophy, cognitive function, studies show
University at Buffalo ^ | Apr 29, 2010 | Unknown

Posted on 04/29/2010 6:30:24 PM PDT by decimon

BUFFALO, N.Y. -- Low vitamin D levels may be associated with more advanced physical disability and cognitive impairment in persons with multiple sclerosis, studies conducted by neurologists at the University at Buffalo have shown.

Their results, reported at the American Academy of Neurology meeting, held earlier this month, indicated that:

* The majority of MS patients and healthy controls had insufficient vitamin D levels.

* Clinical evaluation and magnetic resonance imaging (MRI) images show low blood levels of total vitamin D and certain active vitamin D byproducts are associated with increased disability, brain atrophy and brain lesion load in MS patients.

* A potential association exists between cognitive impairment in MS patients and low vitamin D levels.

The MRI study involved 236 MS patients -- 208 diagnosed with the relapsing-remitting type and 28 with secondary progressive, a more destructive form of MS -- and 22 persons without MS.

All participants provided blood serum samples, which were analyzed for total vitamin D (D2 and D3) levels as well as levels of active vitamin D byproducts. MRI scans performed within three months of blood sampling were available for 163 of the MS patients.

Results showed that only seven percent of persons with secondary-progressive MS showed sufficient vitamin D, compared to 18.3 percent of patients with the less severe relapsing-remitting type.

Higher levels of vitamin D3 and vitamin D3 metabolism byproducts (analyzed as a ratio) also were associated with better scores on disability tests, results showed, and with less brain atrophy and fewer lesions on MRI scans.

Bianca Weinstock-Guttman, MD, UB associate professor of neurology/Jacobs Neurological Institute and director of the Baird Multiple Sclerosis Center, is first author on the study. Commenting on these results, Weinstock-Guttman said: "Clinical studies are necessary to assess vitamin D supplementation and the underlying mechanism that contributes to MS disease progression."

While lower-than-normal vitamin D status is known to be associated with a higher risk of developing MS, little is known about its relationship to cognitive impairment.

Sarah A. Morrow, MD, UB assistant research professor of neurology/Jacobs Neurological Institute and lead author on the cognitive-impairment study, compared vitamin D levels in blood samples of 136 MS patients with the results of their neuropsychological assessments that tested multiple types of cognition affected by MS.

"Results showed that MS patients who were impaired on tests of executive function --critical reasoning and abstract thinking -- and the ability to plan and organize, were more likely to be deficient in vitamin D," said Morrow.

"This relationship held true when controlling for the season during which vitamin D was measured, as well as depression, which is known to be associated with lower vitamin D levels." Morrow noted there also was a suggestion that verbal fluency (word generation) and visual-spatial memory (learning and memory of shapes and figures) is more likely to be affected when vitamin D levels are not sufficient.

###

Morrow is continuing her research to clarify these relationships.

Contributors to the studies, all from UB, were: Robert Zivadinov, MD, PhD; Murali Ramanathan, PhD; Ralph Benedict, PhD; Jun Qu, PhD; Xiaotao Duan, PhD; Barbara E. Teter, PhD; David Hojnacki, MD; Eunjin Bang, Niels Bergsland, Sara Hussein, Mariya Cherneva and Laura Willis.


TOPICS: Health/Medicine
KEYWORDS: multiplesclerosis; vitamind

1 posted on 04/29/2010 6:30:25 PM PDT by decimon
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To: decimon

bump for later.


2 posted on 04/29/2010 6:30:49 PM PDT by brytlea (Jesus loves me, this I know.)
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To: neverdem; DvdMom; grey_whiskers

Ping.


3 posted on 04/29/2010 6:31:01 PM PDT by decimon
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To: decimon

I’ve increased my Vitamin D levels - I’m taking 6,000 units a day. Unfortunately, I have not felt the effects of it.


4 posted on 04/29/2010 6:31:44 PM PDT by diamond6 (Pray the Rosary to defeat communism and Obamacare!!)
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To: diamond6

My Mom has low Vitamin D levels too(her blood test showed it 3 points below normal..she has 27..nothing major) but she took yesterday 50,000 units..she doesn’t take it everyday, she heard that it can cause a heart attack if you take too much so she afraid to take too much


5 posted on 04/29/2010 6:34:40 PM PDT by Sarah Barracuda
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To: decimon

the evidence on vitamin D keeps mounting up! Linus Pauling was on the right track, he just devoted himself to the wrong vitamin. Back when I was a kid, a tan was viewed as healthy, but then they discovered a slight risk between sun exposure and skin cancer and everyone avoided the sun or spread SPF 50 all over their bodies, resulting in lower Vitamin D levels, which they are now discovering is associated with myriad health issues, Is this the “law of unintended consequences” at work again?


6 posted on 04/29/2010 6:46:39 PM PDT by FlyingFish
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To: decimon

btt


7 posted on 04/29/2010 6:49:02 PM PDT by KSCITYBOY
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To: pandoraou812

Vit D ping


8 posted on 04/29/2010 6:55:12 PM PDT by TigersEye (0basma's father was a British subject. He can't be a "natural-born" citizen.)
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To: diamond6

I take 10K a day. It took about 6 months to really see a difference in my overall health.


9 posted on 04/29/2010 7:02:47 PM PDT by Aggie Mama
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To: decimon

“Low vitamin D levels are related to ms brain atrophy”

The dems must be low on their D...


10 posted on 04/29/2010 7:09:18 PM PDT by DeoVindiceSicSemperTyrannis
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To: TigersEye

Thanks!


11 posted on 04/29/2010 7:28:13 PM PDT by pandoraou812 (timendi causa est nescire)
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To: decimon

Important post - thanks.


12 posted on 04/30/2010 7:59:23 PM PDT by GOPJ ("Draw Mohammad Day" - - May 20, 2010 - Draw for freedom - draw for your children't freedom.)
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