In 1986 the National Academy of Sciences targeted fragrances as one of the six categories of chemicals that should be given high priority for neurotoxicity testing. The other groups include insecticides, heavy metals, solvents, food additives and certain air pollutants. The report states that 95% of chemicals used in fragrances are synthetic compounds derived from petroleum. They include benzene derivatives, aldehydes, and many other known toxics and sensitizers - capable of causing cancer, birth defects, central nervous system disorders and allergic reactions. “Neurotoxins: At Home and the Workplace” (Report by the Committee on Science and Technology. U.S. House of Representatives, Sept, 16, 1986) [Report 99-827]
A few chemicals found in fragrances known to be neurotoxic: hexachlorophene; acetyl-ethyl-tetramethyl-tetralin; zinc-pyridinethione; 2,4,dinitro-3-methyl-6-tert-butylanisole; 1-Butanol; 2-butanol; tert-Butanol; Isobutanol; t-Butyl Toluene. Neurotoxic properties of chemicals found in fragrances have caused testicular atrophy in lab animals as well as myelin disease. The myelin sheath protects the nerves and does not regenerate. (Compiled from TOXLINE database of fragrances industry and medical journals.)